Prof. Dr. Gabriele Sadowski
Small molecule pharmaceutics and complex liquid systems
Projects
The bioavailability of an active pharmaceutical ingredient (API) is often limited by its poor water solubility, which is strongly influenced by pH and the presence of salts. This project develops an adequate model to predict the phase behavior of APIs in water and in (lipid-based) drug delivery systems.
Surfactants are used extensively in industrial and pharmaceutical applications, exploiting their effect on the aqueous solubility of hydrophobic compounds. This project aims at developing an aggregation model to be combined PC-SAFT allowing for predicting the formation of surfactant aggregates and their influence on the solubility of pharmaceutical ingredients.
Oil in water emulsions can effectively be used as delivery systems for poorly water soluble drugs. These emulsions are stabilized by surfactants. This project develops a suitable modeling approach for those systems utilizing an aggregation model and PC-SAFT. This will serve as a predictive method capable of describing the complex liquid-liquid phase equilibria in aqueous oil/surfactant solutions.