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Spokesperson

Prof. Dr. Gabriele Sadowski

THERMODYNAMICs FOR FORMULATION DEVELOPMENT

Small molecule pharmaceutics and complex liquid systems

CURRENT

Projects

01/02/2024 - 12/31/2026

Many active pharmaceutical ingredients (APIs) suffer from low aqueous solubility, limiting their bioavailability. Bioavailability can be improved by dissolving the API in a polymer, yielding so-called amorphous solid dispersions (ASDs). This project aims at investigating the influence of coating materials, temperature and relative humidity (RH) on the stability of coated ASDs during storage.

Further information

10/01/2025 - 09/30/2028

Lipid-based formulations have emerged as promising drug delivery systems to enhance the bioavailability of poorly water-soluble drugs. Upon oral administration, these drug delivery systems spontaneously form emulsions in the gastrointestinal tract, stabilized by surfactants. This project aims to extend existing modelling approaches for surfactant systems, combining a model for the formation of mixed aggregates with PC-SAFT, to enable the prediction of drug solubilization in self-emulsifying drug-delivery systems. This project is funded by RESOLV.

Further information

PUBLICATIONS

Sadowski